Main Street Inn

Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been one of Missouri’s finest bed and breakfast establishments. After recently undergoing an extensive year-long renovation, the new owners and innkeeper are thrilled to re-open the Main Street Inn B&B and welcome guests to what will be a truly wonderful experience.  Choose to stay in the:

  • Rendezvous Room, with private entrance
  • The Studio Room, with private entrance
  • La Rose Room
  • Felix Valle Room
  • Audubon Room
  • Trope Ricard Room, with private side porch
  • Suite Sainte Genevieve

All rooms feature fine linens, Wi-Fi, and all the grand amenities you would expect.  Savor a delicious breakfast served from 8:00 until 10:00.  You will truly have an unforgettable experience!

If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.

Contact Information

Main Street Inn
Reservations and Information:

221 North Main Street, Sainte Genevieve, Missouri 63670, United States

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Other Information

  • Hours Open

    Open all day, everyday
  • Seasons Open

    Open all seasons
  • Prices and Fees

    $129-$159 per night plus taxes
  • Accessibility

    One handicapped accessible room is available.
  • Eco Friendly Notes

    Newly remodeled with geothermal HVAC.
  • Locally or Family Owned Notes

    Main Street In has been a locally opened and operated since 1882.
  • Pet Friendly Notes

    A pet friendly room is available