During the winter between 1804 and 1805, the Corps of Discovery resided at Fort Mandan, a location in central North Dakota. Today, visitors can experience exhibits, period artifacts, art collections, and interpreters who will tell stories about the Lewis and Clark Expedition right in the place where the corps themselves once stood. The center is the perfect location to learn about the lives of the Native peoples of the area and all of the accompanying experiences they lived through.

The interpretive center is primarily self-guided, however a short drive away from the center stands a replica of the actual Fort Mandan that Lewis and Clark resided in. Within this fort, there are both self-guided and interpreter-led tours, with experiences focused on the Corps time spent at the fort as they built relationships with the Mandan and Hidatsa peoples. Some other well-known figures such as Sacagawea, Toussaint Charbonneau, and Sheheke-Shote were met at this location, and visitors will have the opportunity to fully dive into learning about these important connections.